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Efficacy and Safety of Once-Weekly Semaglutide Versus Once-Daily Sitagliptin as an Add-on to Metformin, Thiazolidinediones, or Both, in Patients With Type 2 Diabetes (SUSTAIN 2): A 56-Week, Double-Blind, Phase 3a, Randomised Trial

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For women planning pregnancy, discontinuation timing varies by medication: Semaglutide (Wegovy, Ozempic): Stop at least 2 months before planned conception Tirzepatide (Mounjaro): Follow SmPC guidance (typically around 1 month) Liraglutide (Saxenda): No fixed period is specified, but discontinue when planning pregnancy There are theoretical concerns related to these medications during pregnancy

Most of the patients with familial disease are asymptomatic and are discovered through genetic screening in predisposing families