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Future research should characterize GIPR with single-cell ocular transcriptomics, directly compare Tirzepatide with pure GLP-1 RAs for IOP and retinal outcomes across metabolic contexts, and incorporate ophthalmic endpoints in cardiometabolic trials to better define the risk-benefit profile

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Author Contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas