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Preclinical studies have indicated that GLP1RAs, such as tirzepatide, may directly impact the vasculature by enhancing endothelial function and decreasing inflammation, which are important in preventing atherosclerosis[30]

As for long-term use, these medications are generally well-tolerated for extended periods

doi: 10.1016/j.apsb.2024.03.011 [DOI] [PMC free article] [PubMed] [Google Scholar] 105.Apperloo EM, Neuen BL, Fletcher RA, et al

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