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13 Metformin may cause gastrointestinal side effects, which are usually less severe than with semaglutide

[DOI] [PMC free article] [PubMed] [Google Scholar] 118.Pratley RE, Aroda VR, Lingvay I, et al

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The appetite-suppressing effects become more pronounced as you build to steady-state concentration over 4 to 5 weeks and titrate up to higher doses
