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The CagriSema metabolic preservation mechanism, specifically the maintenance of mitochondrial function in skeletal muscle during weight loss, could theoretically slow the rate of weight regain by preventing some of the metabolic adaptation that makes regain almost inevitable

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A protein shake and fruit can absolutely count

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10.1111/dom.12885 137 SuhailM.SohrabS

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Vitamin B12 is particularly important to monitor, as metformin is known to impair B12 absorption

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Data Availability: All relevant data are within the paper and its Supporting Information files

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