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These medications are administered via subcutaneous injection, with dosing gradually increased to minimise gastrointestinal side effects

Exendin-4 enhances the sensitivity of prostate cancer to enzalutamide by targeting AKT activation

Many physicians use a microdosing protocol as an offramp slowly tapering down to allow natural metabolism to adapt

Imaging and single-cell transcriptomic analyses demonstrate that SGLT2 inhibitors and GLP-1 receptor agonists improve kidney tissue oxygenation and perfusion, respectively [124], and act on distinct kidney cell types [125,126], reinforcing a biological basis for additive or synergistic effects

AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease
