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In one report, patients who lost more than five pounds after starting semaglutide showed reductions in TSH, suggesting that thyroid labs may shift during the early weight-loss phase

Furthermore, several novel therapeutic compounds (GIP receptor antagonists and agonists including multiple-targeting compounds) have also shown beneficial glucometabolic and body weight lowering effects in individuals with type 2 diabetes and obesity (40, 41)

Clinical research further reinforces the beneficial effects of GLP-1RAs on DPN

It remains unclear whether these neural antiinflammatory actions of GLP-1 medicines require microglial GLP-1R activity

Briefly, FFAs can reduce the tyrosine phosphorylation of insulin receptor substrate-1 by activating the serine/threonine kinase, thereby aggravating IR (151)