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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Brenta G., Di Fermo F

The first comprises the exendin-4 derivatives (exenatide and lixisenatide), whose structure is based on the peptide sequence of exendin-4, which was isolated from the saliva of the Gila monster lizard (Nauck et al, 2021)

This context of high prevalence, progressive natural history, and multisystemic impact underscores the urgent need for effective, broadly applicable pharmacotherapies

They have also been shown to reduce the rates of major adverse cardiovascular events, comprising non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, in patients with type 2 diabetes mellitus