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However, it caused side effects and withdrawal risks that prompted FDA warnings and lawsuits.
Treatment guidelines focus on nutrition, exercise, and pharmacologic therapies to prevent and manage complications

The data is derived from STEP trials (Semaglutide) and the SURMOUNT-1 trial (Tirzepatide), both of which assessed these medications in overweight or obese individuals

Randomized controlled trials indicates that combination therapy achieves greater reductions in HbA1c compared with either agent alone
