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Instead of guessing whether to increase dose, switch compounds, or try a different medication class, PlexusDx uses your genetic data to predict your most likely response pattern

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An in vitro study using GnRH neurons of adult male mice demonstrated that both GLP-1 and Ex4 might excite GnRH neurons, either directly or indirectly by modulating the nitric oxide (NO) and endocannabinoid pathways that control the presynaptic excitatory GABA-ergic inputs to GnRH neurons [36]

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In this context, retatrutide, a new GIP/GLP-1/GCG RA administered once weekly, is currently under investigation for chronic weight management and associated complications [5,9,13]