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36 The attachment of long fatty acids relayed by a carboxylic linkage leaves the affinity and activity almost unaffected

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6 MAR709 had finished its Phase 2a clinical trial in 2017, 51 and it is a balanced dual agonist for GLP-1R and GIPR

Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility

"Despite obesity being recognized as a serious chronic illness with long-term consequences, it's often misclassified as a lifestyle choice, resulting in many employers and the federal government excluding medications like Zepbound from insurance coverage," said Jonsson