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How GLP-1 Medications Work and Why Food Choices Still Matter GLP-1 medications work by influencing several key systems in the body: They slow gastric emptying, meaning food stays in the stomach longer They increase feelings of fullness after smaller meals They reduce hunger signals in the brain They improve insulin sensitivity and blood sugar control While these effects reduce calorie intake, they also change how the body tolerates food

Roche indicated that patients seeking maximum weight loss might choose more potent therapies like its experimental dual-acting enicepatide, while others might prefer more modest weight loss with fewer side effects for easier long-term adherence

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Branded injectables may be expensive without coverage