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[5] Beyond alleviating hot flashes, oral estradiol improves vulvovaginal atrophy, preserves bone mineral density, and may enhance sleep quality and mood, yet systemic treatment introduces cardiometabolic and oncologic trade-offs whose magnitude depends on age at initiation, dose, route, and comorbid risk factors

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If you are using oral birth control, you should also use condoms or another form of contraception for four weeks after starting the medication and for four weeks after each dose increase
