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Pharmacological characterization shows tirzepatide is an imbalanced agonist with full efficacy at GIPR but only partial efficacy at GLP-1R, exhibiting biased signaling that favors cAMP over -arrestin recruitment
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[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Sjostrom L, Peltonen M, Jacobson P, Ahlin S, Andersson-Assarsson J, Anveden A, et al
