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1,220 PKA, a key enzyme, phosphorylates various target proteins, affecting their activity and function, which in turn promotes insulin synthesis and secretion

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(By comparison, Novo Nordisks best-seller Wegovy/Ozempic brings in similar multi-billion revenues, but Lillys CAGR in recent quarters has been higher.) Analysts attribute Lillys success to tirzepatides superior weight loss in trials and aggressive marketing