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The central nervous system was previously thought to be an immunologic sanctuary due to its BBB, acting independently in protecting the brain from disease

A further sensitivity analysis (sensitivity analysis 3) used a MAIC approach utilizing SUSTAIN 7 results corresponding to week 36 (obtained from linear interpolation between the week 28 and week 40 visits) to assess the impact of the difference in time points at which outcomes were reported in the trials

SMC Chair Dr Rob Peel said: "Semaglutide will provide a useful treatment option to help reduce major cardiovascular events in patients who are overweight and have cardiovascular disease." Speaking after the announcement, Sebnem Avsar Tuna, General Manager Novo Nordisk UK said: We are delighted that the SMC has recognised the value semaglutide can bring to the people in Scotland who are living with established cardiovascular disease and overweight or obesity, where the threat of a secondary event is a constant reality