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Endocrine Effects of Soluble DPP4 on Cardiovascular Homeostasis Although it is well established that serum levels of sDPP4 are altered in several pathological conditions and that sDPP4 is released from vascular cells, only a minor part of research has focused on potential endocrine effects of this proteolytic enzyme

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The presence of GLP-1 receptors in the central nervous system, particularly in the ventral tegmental area (VTA) and nucleus accumbens (NAc), suggests their involvement in reward processing and motivation