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For most people, yes, if their doctor has cleared them for exercise

In the STEP 1 semaglutide trial (Wilding et al., NEJM , 2021) and the SURMOUNT-1 tirzepatide trial (Jastreboff et al., NEJM , 2022), nausea affected roughly 44% of semaglutide patients and about 24% of tirzepatide patients at the maximum dose

doi: 10.1111/resp.12312 41 AustinPC

Following the 800 mg dose, the maximum increase in the placebo-corrected mean change in QTc from baseline was observed at 3 hours postdose and was 8.0 msec

People with IBS, especially those with constipation-predominant symptoms or a history of post-infectious IBS, may already have altered gut motility, which could increase vulnerability