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Physician 102 , 603612 (2020)

11,227,228 Islet alpha-cell GLP-1R knockout mice were unable to inhibit glucagon secretion at high glucose levels, and surprisingly, these mice exhibited reduced glucagon secretion during low glucose conditions

This was an essential asset for humans in evolution, but in the modern world where we are surrounded by food, it is a liability. Kennedy noted that, in addition to serving as a standalone option, Calocurb is being used by practitioners as patients come off GLP-1 agonists because it restimulates the bodys own production of GLP-1, and CCK/PYY, re-establishing that gut-brain connection