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Evidence of past weight loss attempts: Some plans require proof of previous diet and exercise attempts before approving GLP-1s

caution is needed for patients with a history of medullary thyroid cancer

A drug with $2 billion in annual revenue and a single, broad CoM patent expiring in four years is a fundamentally different asset than one with the same revenue protected by a deep secondary thicket extending twelve years

Knockdown of GLP1 receptors within the CNS also failed to alter baseline blood glucose levels (Table 2), supporting a principal action for GLP1 in the periphery for proper basal glycaemic control (Sisley et al., 2014)

Semaglutide (weight loss doses): At the 2.4mg dose (Wegovy), average loss reaches approximately 15%