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Effect of Weekly Subcutaneous GLP-1 Shots vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial

The fix: When escalating to a new dose, consider temporarily shifting to evening injection for 1 to 2 weeks

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Insurance companies typically base coverage decisions on factors like approved indications, clinical evidence, and professional guidelines

Less urgent but still worth reporting: side effects that do not improve after seven days at any dose level, persistent diarrhea that interferes with daily activities, significant hair thinning (which can occur during rapid weight loss phases and may relate to nutritional deficiencies rather than medication directly), mood changes including increased anxiety or depression, and hair loss patterns that seem disproportionate to weight loss speed