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Learn about dose escalation Getting your patients started Important Safety Information for Wegovy WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

Below: the standard 8-on/8-off protocol, week-by-week titration math, side-effect-driven adjustments, and how community doses compare to the trial-published 12 mg/week ceiling

doi: 10.1186/s13063-019-3259-x [DOI] [PMC free article] [PubMed] [Google Scholar] 202.Egefjord L, Gejl M, Mller A, et al

Whether you inject Tuesday evening or Wednesday morning, the appetite-controlling effect spans the entire week

Using ANCOVA to adjust EE for lean mass after treatment, we found no difference between semaglutide and vehicle control (Supplemental Figure 1)