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The Paschou paper directly states: GLP-1 receptor agonists "can act on adipose-derived stem cells (ADSC) and fibroblasts, that present GLP-1R on their surface

Endothelial GLP-1R has been shown to be involved in endothelial dysfunction in a mouse angiotensin II-induced hypertension model (Helmstadter et al., 2020)

At lower doses, the average weight loss was still in the 15% range, which remains a remarkable figure by historical standards

These findings help explain why females often experience stronger appetite suppression and weight loss on these drugs and suggest that the benefits of GLP-1 analogs could extend to sex-specific treatments for addiction, depression, and even Alzheimers disease

Obesity is a well-established risk factor for lymphedema development and progression, particularly in cancer survivors, as documented in NCCN Survivorship Guidelines and National Lymphedema Network position papers