is tirzepatide better than metformin SURPASS‑EARLY evaluated starting early in type 2 diabetes vs. conventional step-therapy. In adults with early T2D on metformin, tirzepatide produced larger 2‑year reductions in HbA1c, weight, and waist circumference intensified Mounjaro and Metformin: A Head-to-Head

Tirzepatide is generally more potent for weight loss because it activates both GLP-1 and GIP receptors, whereas semaglutide activates only GLP-1 receptors

The STEP-1 trial tested the effect of high-dose semaglutide to produce weight loss in people with obesity who do not have diabetes

Metabolic changes associated with improved glycaemic control and weight reduction might also play a role

[DOI] [PubMed] [Google Scholar] 98.Jensterle M., Salamun V., Kocjan T., Vrtacnik Bokal E., Janez A

[PUBMED Abstract] Daniels GF, McNeal JE, Stamey TA: Predictive value of contralateral biopsies in unilaterally palpable prostate cancer