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Immunohistochemical staining The presence of GLP-1R in OA human knee joint sections harvested following arthroplasty and non-OA mouse knee joint sections harvested following a mouse study was evaluated using immunohistochemical staining

Additionally, excluding patients with a diagnosis of any psychiatric diseases within one year before or one month after the index date may not be sufficient to avoid bias

A key debate is whether lean mass decline in GLP-1-treated patients should be framed as an adverse event or as an expected physiological corollary of negative energy balance

Nat Rev Endocrinol 19 , 201216 (2023)

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