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Moreover, mice with targeted inactivation of GLP-1R in autonomic neurons targeted by Phox2b, including the nodose ganglion, exhibit impaired glucose homeostasis, accelerated gastric emptying, and increased levels of GLP-1, glucagon, and insulin, supporting the importance of vagal afferent GLP-1Rs for metabolic homeostasis [520]

doi: 10.1152/ajpendo.1996.271.3.E458

GLP-1 agonist receptors mimic this naturally occurring hormone

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Patients consistently had improved glycemic levels and multiple drugs, such as tirzepatide alone or semaglutide in combination with cagrilinitide, were highly effective at promoting weight management