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At the end of the study, patients who had metabolic surgery had a: 32% lower risk of death 35% lower risk of major heart problems (such as heart attack, heart failure, or stroke) 47% lower risk of serious kidney disease 54% lower risk of diabetes-related eye damage (retinopathy) On average, people who had metabolic surgery lost 21.6% of their body weight over 10 years, compared with 6.8% weight loss in people who took GLP-1 medicines

If youve missed more than 2 weeks of doses, contact your healthcare provider for guidance

They also act on the appetite centers in the brain, significantly reducing hunger and what is often called food noise. The dual-action drug tirzepatide works on both GLP-1 and GIP receptors, often leading to even greater efficacy

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In fact, retention in the retatrutide program was relatively strong, suggesting that this stepped approach succeeded in keeping participants engaged long enough to generate reliable data