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Here is how the two formats compare clinically: Do GLP-1 Medications Cause Muscle Loss

[DOI] [PubMed] [Google Scholar] 37.Drucker D.J., Buse J.B., Taylor K., Kendall D.M., Trautmann M., Zhuang D., Porter L., DURATION-1 Study Group Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study

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The risk magnitude rises with the severity of liver disease in NAFLD, particularly at higher fibrosis stages [42]

GLP-1 receptor agonists induce loss of lean mass: So does caloric restriction