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Start at the low end and increase gradually based on tolerance and results

Given the substantial disease burden and adverse health outcomes associated with this comorbidity, interventions aimed at reducing this risk for depression in the Type 2 diabetes population are crucial, particularly among older adults who are disproportionately affected by both conditions. Guo noted that previous research suggested that GLP-1RAs a drug also used to treat obesity and kidney disease may alleviate depression symptoms due to its ability to cross the blood-brain barrier

Successful and sustainable weight loss indeed includes lifestyle changes

Concerns with Unapproved GLP-1 Drugs Used for Weight Loss

doi: 10.1001/jama.2016.0048