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Furthermore, the substrate recognition is also dependent on the aa sequence around the penultimate position (61, 62)

Diabetologia (2006) 49:25360

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GLP-1 receptor agonist medications represent a conceptually-grounded, mechanism-based intervention

Structurally, GLP-1R comprises a large extracellular N-terminal domain responsible for ligand binding, seven transmembrane -helices, and an intracellular C-terminal domain that interacts with G proteins and other signaling molecules [15]