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Annu Rev Physiol 76: 535-559, 2014

Summary Although GLP-1R agonists were originally developed for glycemic control in DM, their mechanistic versatility has enabled broader application across a spectrum of cardiovascular, cerebrovascular and metabolic disorders

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Transient transfection, as above, was used to deliver DNA encoding mouse GLP-1RLgBiT and ARRB1/2-SmBiT fusion proteins

Other side effects of GLP-1 drugs Gastrointestinal symptoms - nausea, vomiting, diarrhea, and constipation - are by far the most common side effects of GLP-1 drugs