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Gradual dose increases improve effectiveness while reducing the risk of side effects

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Fifty percent of our cohort maintained a dose of semaglutide of 1.0 mg weekly, with the majority of patients taking a maximum dose of 0.5 or 1.0 mg

The SECRET trial evaluated 20-week LED and/or ET interventions and revealed that significant increases in the VO 2 peak could be achieved using either of these approaches, although neither improved the total score on the Minnesota Living with Heart Failure (MLHF) questionnaire
