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All trials analyzed the composite of 3 major adverse cardiovascular events (MACE), which included cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke, except the lixisenatide study that considered 4-point MACE, which also included hospitalization for heart failure (Table 1).5764 Although all the studies with arGLP-1 have demonstrated cardiovascular safety (noninferiority vs