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Improvements in 5-HT production occur by increasing EC expression of tryptophan hydroxylase, the rate-limiting enzyme in EC 5-HT production 288 , or by increasing microbial metabolites, such as SCFAs and BAs, that are known to stimulate EC 5-HT production 74

Women in perimenopause or menopause may be dealing with declining estrogen and testosterone that no amount of weight loss will correct

Pharmacokinetics (How Long They Last): Semaglutide: Half-life: Approximately 7 days Reaches steady state: After 4-5 weeks Duration of action: Remains active for one week between doses Time to peak concentration: 1-3 days after injection Tirzepatide: Half-life: Approximately 5 days Reaches steady state: After 4 weeks Duration of action: Remains active for one week between doses Time to peak concentration: 8-72 hours after injection Both medications are designed for once-weekly dosing and maintain therapeutic levels throughout the week

Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells