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Pioneer 5: This trial demonstrated the efficacy of semaglutide on 324 subjects with modest kidney issues, who received either once-daily oral 14.0 mg semaglutide (163), or placebo (161) along with previous antidiabetic therapy

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Because the upper limit of the two-sided 95% CI for the estimated differences was below 0 kg, superiority of SEM 0.5 mg or SEM 1 mg versus placebo in change in body weight was demonstrated

In clinical trials, Semaglutide has shown effectiveness in reducing HbA1c levels, aiding weight management, and improving cardiovascular outcomes in people with diabetes