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This means that the overall effectiveness of treatment depends on consistent weekly use rather than perfect timing of a single injection

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A non-peptide GLP-1 pill called orforglipron is also showing promising results

Descriptions and sources of reagents and detailed methods of our mouse models of experimental MI in vivo (66), IRI in vivo (67), IRI ex vivo (4, 21), as well as mouse and human cellular injury models in vitro (21, 68) are provided in the Supplemental Methods

They also found that people who struggled with gastrointestinal side effects were more likely to quit