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J Clin Endocrinol Metab 17:1263

However, this increased efficacy comes with the profound responsibility of careful patient selection, rigorous symptom monitoring, and the absolute necessity of comprehensive lifestyle support

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If your BMI is below 27, the realistic path forward involves focusing on the health conditions that could qualify you through the comorbidity pathway if your BMI is at least 27, or working with a provider who assesses your metabolic risk beyond the BMI number alone
Because it is metabolized primarily in the liver without the formation of active metabolites, glipizide is the preferred sulfonylurea in patients with renal disease (40)
