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There was a steady rise in the use of these drugs in these countries, especially GLP-1R agonists in the U.S., in the periconceptional period

Am J Physiol Endocrinol Metab 299: E62-68, 2010

10.1172/JCI116186

Since IR governs the pathogenesis of NAFLD, the possible role of PIO in this setting gained special interest during the last two decades
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