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Studies suggest that in diet-induced insulin-resistant rodents, insulin-mediated skeletal muscle microvascular blood flow is impaired post-short-term high fat feeding, and this occurs before the development of myocyte or whole-body insulin resistance

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Concurrent use of DPP-4 inhibitors with a GLP-1 receptor agonist is not recommended due to lack of additional glucose lowering beyond that of a GLP-1 RA alon...

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Research suggests that GLP-1 users prefer sugar to artificial sweeteners, as they are increasingly attracted to more 'natural' food that feels 'worthwhile' with their smaller appetites