glp-1 articles Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists on Body Weight and Cardiometabolic Parameters in Individuals With Obesity and Without Diabetes: A Systematic Review and Meta-Analysis Is biased agonism helpful in
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doi: 10.2337/db21-0688 [DOI] [PubMed] [Google Scholar] 148
Semaglutide 1.0 mg slowed the loss of kidney function as measured by eGFR
However, evidence from human cell-based experiments suggests that these benefits are unlikely to result from direct actions on hepatocytes or HSCs, instead reflecting indirect metabolic and anti-inflammatory mechanisms
