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In similar experiments in another transgenic animal model, overexpressing human islet amyloid polypeptide did not reveal any ductal abnormalities (histology) or a change in ductal cell proliferation rates with sitagliptin, metformin, sitagliptin with metformin, or placebo treatment (15)

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The patients family history was noncontributory except for an uncle with a diagnosis of Graves disease and a brother with asthma

The lack of head-to-head trials means that direct comparisons must rely on cross-trial analyses, which are inherently less reliable than randomised controlled trials

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