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Some clinicians have adopted this reasoning and prescribe both medications off-label, particularly phentermine combined with semaglutide or phentermine combined with tirzepatide

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Rapid dose escalation doesnt give the body enough time to adjust, often leading to more intense GI symptoms

In addition, GIP stimulates the transcription of -cell insulin gene [34]

Notably, combination therapy with pramlintide (360 g twice daily) and metreleptin (5 mg twice daily) produced considerable weight loss (mean 12.7 kg) over 20 weeks in overweight or obese human subjects [17]