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To help ease side effects, we recommend: Eating smaller, slower meals Prioritizing protein and staying well hydrated Avoiding greasy, heavy, or highly processed foods Not lying down immediately after eating Staying at the lowest effective dose for as long as appetite suppression is working If side effects feel intolerable , persistent, or unusual, or if something simply doesnt feel right, please contact your provider right away

Obese mouse models (Coskun 2022) show basal energy expenditure +8-12% vs vehicle, a major contributor to the magnitude of weight loss observed in phase II clinical trials

Reprogrammed cells expressed key transcription factors of -cell identity (Pdx1, MafA, FoxA2), while the morphology and function of the rat intestinal epithelium remained intact (Duan et al., 2015)

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Management follows standard GORD guidance (NICE CG184), including lifestyle changes, alginate antacids, and PPIs where appropriate