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The renal interstitium showed a significantly greater level of tubular hypertrophy and vacuolar degeneration in the diabetic groups than in the non-diabetic group

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It is recognized by pattern receptors and mediates the LPS-CD14-TLR4 signaling pathway, which activates intrahepatic KCs

However, several clinical studies have shown that the diagnosis of prediabetes already defines a high cardiovascular risk independently of other risk factors [36, 37]

Br J Haematol