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ClinicalTrials.gov TRIUMPH-1: A Master Protocol to Investigate the Efficacy and Safety of Retatrutide (LY3437943) Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Overweight (NCT05929066)
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These findings suggest that structural or functional dysregulation of the hypothalamus plays a critical role in the hyperphagia and obesity associated with PWS

9 GLP-1 agonists are contraindicated during pregnancy due to safety concerns, because they restrict foetal growth when given to experimental animals
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Summary Pulling the new reports together, there is further momentum and excitement building for GLP-1 drug expanded use beyond diabetes and obesity
