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Despite the strength of this meta-analysis including a large cumulative sample size, exclusive use of RCTs, and comprehensive subgroup analysis some limitations must be acknowledged

SELECT CVOT trial investigated the cardiovascular safety of semaglutide 2.4 mg therapy once a week in a group of 17,605 overweight or obese adults over the age of 45 with no history of T2DM

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The interaction of substances can cause side effects such as severe nausea, hypoglycemia, and gastrointestinal distress