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Here's why: The price difference is real but you get what you pay for

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Retatrutides higher discontinuation rate due to adverse events, combined with the dysesthesia signal, places a greater tolerability burden on participants compared to tirzepatide [3]

Since April 22, 2025, 503A enforcement discretion ended, and the FDA proposed in April 2026 to exclude semaglutide, tirzepatide, and liraglutide from the 503B Bulks List