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Taken together, these findings indicate that tirzepatide enhances -cell transcriptional programs through reactivation of the FOXO pathway, positioning it as a central mediator of -cell function restoration

12-14 As many patients with T2DM are overweight or obese, a drug that can help patients achieve any amount of weight loss is often welcomed by patients and physicians alike

Informed Consent Statement This study was based on publicly available data, and the corresponding consent statement was provided in the original publications

Impact of weight loss with diet or diet plus physical activity on cardiac magnetic resonance imaging and cardiovascular disease risk factors: Heart Health Study randomized trial

Supervised exercise programs through CMCs rehabilitation center and gym provide additional support as patients become more active