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Given the eminent global opioid crisis, development of GLP-1RA is an important research goal [106]
As GEP44 acts directly on muscle tissue, while its effects on islets require concomitant Y1-R antagonism, activation of Y1-R expressed in muscle tissue may ultimately prove to be a critical factor in reducing serum glucose levels, alongside any potential effects on insulin secretion and glucagon release
10.1016/j.celrep.2019.05.055 [DOI] [PubMed] [Google Scholar] Verdich, C
Early clinical trial data suggests it could deliver even greater weight loss potential than current treatments on the market
doi: 10.1007/s00125-013-2892-2 305 HasibANgMTTandayNCraigSLGaultVAFlattPRet al
