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They do this in several ways: They boost insulin release when blood sugar rises They reduce glucagon (a hormone that increases blood sugar) They slow down stomach emptying, which prevents blood sugar spikes after meals For people with type 2 diabetes, these effects can mean better control of blood sugar levels and lower A1C (a measure of average blood sugar over time)

In line with the latter, GLP-1 have been shown to protect from ischaemia/reperfusion injuries in isolated perfused rat hearts (Bose et al., 2005)

Rim Masri, Faculty of Medical Sciences, Lebanese University, Hadath, Lebanon

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[4] Clinical trials [edit] Retatrutide has been studied in a phase 2 trial involving adults without diabetes but with obesity or preobesity (overweight)